Ingabe ukudla kwe-vegan kungashintsha indlela izakhi zethu zofuzo ezisebenza ngayo? Ithimba labacwaningi likhombisile ukuthi, emavikini amane nje kuphela , ukudla okusekelwe ezitshalweni kungabangela izinguquko ezilinganisekayo ku-DNA, okunemiphumela ekuvuvukeni nasekugugeni kwezinto eziphilayo. Nakuba imiphumela ingeyokuqala, ivula umnyango wokuqonda ukuthi lokho esikudlayo kuyithinta kanjani impilo yethu ezingeni lama-molecule.
Lolu cwaningo, olushicilelwe ephephabhukwini i-MedComm, lulandele abantu abadala abangu-48 abanempilo inyanga eyodwa. Ingxenye yalandela ukudla okuqinile kwe-vegan, kanti ingxenye yalandela ukudla okucebile enyameni okunama -calories afanayo . Ukuhlolwa kwegazi kwembule ukuthi iqembu le-vegan labhekana nezinguquko ku-methylation ye-DNA, indlela elawula umsebenzi wezakhi zofuzo, ehlotshaniswa nokuncipha kokuvuvukala kanye nokwehla kokuguga kwezinto eziphilayo.
Lena yindlela okuqhutshwe ngayo ukuhlolwa
Abahlanganyeli, bonke abaphilile futhi abaneminyaka ehlukahlukene, babelwa ngokungahleliwe kwelinye lamaqembu amabili. Kwaphela amasonto amane, iqembu elilodwa lilandela ukudla kwe-vegan okusekelwe ezithelweni, imifino, ubhontshisi, kanye nokusanhlamvu, kanti elinye lidla inyama nsuku zonke. Ukuze kuvinjelwe ukwehla kwesisindo ekuthonyeni imiphumela, womabili amaqembu adle inani elifanayo lamakhalori.
Ngaphambi nangemva kwesikhathi sokuhlola, abacwaningi bathathe amasampula egazi futhi bahlaziya izindawo ezingaphezu kuka-800.000 ze-genome lapho kwenzeka khona i-DNA methylation. Le nqubo yamakhemikhali isebenza njengoshintsho oluvula noma oluvala izakhi zofuzo, futhi ingathinteka yizici zangaphandle njengokudla.
Yiziphi izinguquko ezibonwe
Eqenjini lama-vegan, ukuhlaziywa kubonise ukwehla kwama-neutrophils , uhlobo lweseli lokuzivikela komzimba elihlotshaniswa nokuvuvukala, kanye nokwanda kwamaseli e-CD4+, okusiza ukulawula impendulo yokuzivikela komzimba. Leli phethini lisikisela ukuthi ukudla okusekelwe ezitshalweni kungaba nomphumela wokulwa nokuvuvukala.
Ngaphezu kwalokho, kwatholakala izinguquko emsebenzini wezakhi zofuzo ezihilelekile ekugayweni kwezakhi zofuzo, ukulungiswa kwe-DNA , kanye nezindlela eziningana ezihlobene nomdlavuza. Kwaphinde kwabonwa izinguquko ezingakhuthaza ukwehla kwe-cholesterol, impendulo ye-insulin ethuthukisiwe, kanye namandla amakhulu okulungisa umonakalo ezintweni zofuzo.
Ukuze balinganise ukuguga kwezinto eziphilayo, ososayensi basebenzise "amawashi" amaningana asekelwe ku-DNA. Amabili awo, i-PhenoAge ne-GrimAge , agxile ezinkombeni zezempilo, akhombe ukwehla kokuguga eqenjini labantu abadla imifino kuphela. Kodwa-ke, elinye iwashi elibizwa ngokuthi i-Blood&Skin libonise ukuthambekela okuphambene, okubonisa ukuthi imiphumela ayivumelani.
Implicaciones para la salud
Lokhu okutholakele kuqinisa umqondo wokuthi ukudla okunempilo kungabumba i-biology yethu ezingeni lama-molecule. Ngokusho kukaJerome Mertens, uprofesa ohlangene we-neuroscience e-University of California, eSan Diego, "izakhi zofuzo zethu azizona iziphetho zethu." Umcwaningi ugcizelele ukuthi i-epigenome yasabela ngendlela elinganiswayo emavikini amane nje kuphela, okubonisa ukuthi i-biology inamandla kakhulu kunalokho okwakucatshangwa ngaphambili.
Naphezu kwalezi zimpawu ezithembisayo, abalobi bocwaningo baqaphile . Lolu cwaningo luncane futhi luhlala isikhathi esifushane, ngakho-ke akunakuphethwa ngokuthi ukudla kwe-vegan kunciphisa ngqo ingozi yesifo. UMax Storz, udokotela e-University Medical Center of Freiburg eJalimane, waphawula ukuthi isinyathelo esilandelayo ukuthola ukuthi lezi zinguquko ze-epigenetic ziyaqhubeka yini ngokuhamba kwesikhathi nokuthi ziholela ekuthuthukisweni kwangempela kwezempilo.
Imikhawulo nezinyathelo ezilandelayo
Ucwaningo luhlanganise abahlanganyeli abangu-48 kuphela futhi lwathatha inyanga eyodwa kuphela, okunciphisa ukujwayelana kwemiphumela. Ngaphezu kwalokho, izinguquko ezibonwe ekugugeni kwezinto eziphilayo azizange zihambisane kuzo zonke iwashi ezisetshenzisiwe, okugqamisa ubunzima bokulinganisa lesi simo.
Abacwaningi manje bahlela ukwenza izivivinyo zemitholampilo ezinkulu nezinde ukuqinisekisa ukuthi imiphumela ingeyesikhathi eside futhi inomthelela wangempela ekuvimbeleni izifo. Bafuna futhi ukuphenya ukuthi lezi zinguquko ze-epigenetic zingaguqulwa yini ngokuyeka ukudla kwe-vegan.
Ngamafuphi, lolu cwaningo lunezela ubufakazi emcabangweni wokuthi lokho esikudlayo kungathonya indlela izakhi zofuzo zethu ezivezwa ngayo . Kodwa ochwepheshe baphikelela ngokuthi akufanele sithatheke: lesi yisinyathelo sokuqala nje, futhi kuzodingeka ucwaningo olubanzi nolude ukuze kuqinisekiswe ukuthi lezi zinguquko zihumusha yini zibe izinzuzo zangempela zezempilo. Okwamanje, labo abakhetha ukudla kwe-vegan kufanele bakhumbule ukuthi ukuhlela kuyisihluthulelo sokugwema ukuntuleka kokudla okunempilo, ikakhulukazi i-vitamin B12, i-iron, ne-calcium.
